The award was presented by Miranda Lambert, who won in the same category 18 years ago.
The show will air one week before the Golden Globes, which has traditionally kicked off awards season.
The Catalyst of Change honor was presented to her by Lily Allen on Thursday night (April 24).
"Our stories, our voices and our cultures deserve to be celebrated."
The iconic regional Mexican star and rising sibling trio delivered a heartfelt ballad at the third annual celebration.
On the year of her centennial, the Queen of Salsa is celebrated posthumously with the Legend Award.
The sister duo accepted the Unbreakable Award from Prince Royce.
The Mexican American singer wowed with a medley of "Qué Me Vas a Dar" & "Por Qué Soy Abeja Reina," while earning the Impact Award.
The trilingual Brazilian superstar was honored the Vanguard Award at this year's third annual ceremony.
He has won four Tony Awards.
