The reggaeton stars sang their new track for the first time on television.
Before kicking off the live broadcast, stars such as Becky G, Anuel AA, David Bisbal, Chiquis and Pepe Aguilar walked the red carpet.
The top nominees of the night are Karol G, Bad Bunny, Daddy Yankee and Becky G.
Spanish-language acts delivered epic sets at the festival during weekend one.
The couple sang two songs off RR, their joint EP released in March.
Peso Pluma and Natti Natasha joined Becky as her surprise guests during her Friday set.
The Puerto Rican hitmaker also delivered a lengthy heartfelt speech, in which he said, "don't believe everything you hear."
The Live Nation-produced outing will kick off Aug. 26 in Chicago.
The agreement expands the artist's relationship with the label after previously singing with Sony Music Entertainment Chile.
Plus, Latin Women In Music honorees were announced.
