The ceremony will take place Thursday, Oct. 5.
The Colombian superstar receives Billboard's Spirit of Hope award for her work with the foundation during the Billboard Latin Music Awards.
"We are all ready to party," says producer Mary Black-Suárez.
Chiquis, El Alfa, Eladio Carrión, Justin Quiles, Los Ángeles Azules, Marshmello, Tini and Yandel are also among the performers at this year's awards show.
The Mexican hitmaker earns 21 nods. Here's a breakdown of his 15 category entries, including the coveted Artist of the Year and Artist of the Year, New.
From Karol G to Bad Bunny, we break down the top category.
Save the date to Latin music's longest-running and biggest gathering in the world!