The singer previously voiced her support for the Palestinian people in her "Next 2 U" video.
The Fat Joe & Friends Relief for Haiti fund will aide the country and provide portable mattresses, pillows, blankets, diapers and more.
The moment has fans comparing the couple to American “royalty."
The donation from Abel Tesfaye's XO Humanitarian Fund will be used to provide more than 1,500 metric tons of fortified wheat flower to Palestinians.
The Grammy-nominated artist will perform at a fundraiser in Los Angeles.
The Migos rapper dropped into Dunbar High School before his Set It Off tour stop earlier this week.
The fundraiser was also attended by Jelly Roll, The War and Treaty and more.
The Weeknd has partnered with the L.A.-based organization School on Wheels to support more than 1,000 students experiencing homelessness.
The Who, Noel Gallagher, Chemical Brothers, Eddie Vedder and Robert Plant will play the March concerts.
The musician has a long history of donating her earnings.
