The Grammy-nominated artist will perform at a fundraiser in Los Angeles.
The Migos rapper dropped into Dunbar High School before his Set It Off tour stop earlier this week.
The fundraiser was also attended by Jelly Roll, The War and Treaty and more.
The Weeknd has partnered with the L.A.-based organization School on Wheels to support more than 1,000 students experiencing homelessness.
The Who, Noel Gallagher, Chemical Brothers, Eddie Vedder and Robert Plant will play the March concerts.
The musician has a long history of donating her earnings.
The United Nations World Food Programme Goodwill Ambassador has directed $2.5 million from his fund toward's WFP's response in the Palestinian territory.
Nikki Sixx, Tommy Lee, Todd Sucherman and Styx, Matt Sorum, Fred Armisen and more have also given items for the cause.
Counting Crows and Katharine McPhee are also set to perform.
100% of the proceeds from the Wiltern concert will benefit his Heart and Armor Foundation.