His band the Bluesbreakers was a training ground for Cream's Eric Clapton and Jack Bruce, Fleetwood Mac's Mick Fleetwood, John McVie and Peter Green, and more.
Fakir, who co-founded The Four Tops in 1953, had been in poor health, most recently fighting bladder cancer.
"This one hurts," Bieber wrote of his late friend and onetime roommate.
He handled albums from Buddy Guy, Bonnie Raitt and Lou Rawls and box sets of music from the likes of Nat King Cole, Miles Davis, Billie Holiday, T-Bone Walker and Amos Milburn.
He recorded for Disques Vogue and Columbia Records, appeared in films including Asphalte and The Devil's Brigade and voiced one of the Merry Men in Shrek.
"It brought him great joy to know, that for decades, his music touched so many and will be his lasting legacy," his wife Amy Carmen writes.
Lawrence's late wife, singer Eydie Gormé, was his "partner on stage and in life" for more than 55 years.
"Mojo has left the building," a statement announcing the news on his Facebook page reads.
The cause of death was pancreatic cancer, according to a close friend & executive director of Kramer’s nonprofit Jail Guitar Doors.
The musician was fighting ampullary cancer, but toured until he succumbed to his illness.
