The star-studded event is returning for its eighth year during Coachella weekend 1.
Set times for this year's festival were also posted.
"it pains me to say this because i am so excited to bring you a creation that i have poured my soul into," Twigs announces on social media.
A special, yet-announced guest is also confirmed for Saturday, April 12.
Jason Aldean, Brooks & Dunn, Cody Johnson & Keith Urban will also play the annual music fest, which takes place June 5-8 across Nashville.
The festival returns to San Francisco from August 8 to 10.
"This next one is one of my favorite songs that I didn't write," the singer told the crowd.
Other performers include Kim Petras, Honey Dijon, Paris Hilton & more.
This year would have marked her third time at the festival.
The Maine, Authority Zero & Summer Set among bands to headline venue during May celebration.
