"The awards of the soul, helping a friend, serving others, those are the ones that are most worthwhile," the Colombian superstar said after accepting his trophy from Maluma.
The hit is off the regional Mexican act's latest album El Comienzo, which reached No. 4 on the Top Latin Albums chart.
The Puerto Rican superstar is confirmed for the Oct. 5 ceremony, which will air live on Telemundo.