The former contestant's sister shared the news on Facebook.
The star who rose to fame in the early 2000s was found unconscious in his apartment on Monday night (March 10).
The guitarist was surrounded by family as he "passed peacefully" March 6.
The group announced tw days before that he had been experiencing "medical complications."
The influential musician born Charles Chambers was battling stage four cancer.
The senior PR executive worked with Elton John, New Edition, Bobby Brown and other artists during her trail-blazing career.
“Thank you, Joey…for keeping the band’s music alive for so long and for being a friend to us all,” a Facebook post read.
Stone had two No. 1s on the Adult R&B Airplay chart and one on the Top R&B/Hip-Hop Albums chart, and was nominated for three Grammys.
The singer had revealed his cancer diagnosis in February.
"I know great grief is born only of great love," Kylie Jenner wrote in a heartfelt tribute to the late artist.
