Keke Palmer & Gayle King were also cited for their purpose and mission-driven work.
The one-hour special will air on Saturday (Nov. 2) on CBS and CMT.
The musician and the TV star were friends.
The awards were launched in 2021 to highlight social impact work happening around the globe.
MusiCares' relief efforts have helped amid the COVID-19 pandemic, the Las Vegas Route 91 shooting, Hurricanes Katrina, Harvey, Irma, Ida and more.
The honorees include three Pulitzer Prize winners.
Selena Gomez, Eva Longoria, Taraji P. Henson and the Farrelly Brothers are among past recipients of the Morton E. Ruderman Award.
Actor Jon Cryer and his wife, actress and producer Lisa Joyner, will co-host the event.
Singer-songwriter Natasha Bedingfield is set to perform at the Sept. 26 event.
The award recognizes his efforts on behalf of the LGBTQ community and in fighting HIV/AIDS.
