Sheryl Lee Ralph will receive the inaugural Sheryl Lee Ralph Legacy Award.
The award will be presented at the 43rd annual John Lennon Tribute on Dec. 2 at Town Hall in New York.
The late philanthropist and wife of music industry legend Clarence Avant "was a collector of souls who wanted to make sure everyone got the chance to fly."
The Nashville-based cancer charity rebounds after a former executive was found guilty of embezzling $4 million from the organization.
The money, which will be donated over the next five years, marks the largest single donation in the foundation's history.