Lil Wayne ran through five cuts off his Tha Carter series of albums for his SNL50: The Anniversary Special appearance.
The four-season Saturday Night Live castmember paid tribute to his late castmates Chris Farley, Phil Hartman & more.
O'Connor famously tore up a photo of then-Pope John Paul II to end her 1992 Saturday Night Live performance.
The show will take place at 8 p.m. ET on Feb. 14, and will also stream live on Peacock for viewers at home.