The singer has been open throughout his career about living with Type 1 diabetes.
David Ortiz, Emmitt Smith, Lisa Leslie & Julius Erving also make appearances in the spot.
The married rap duo performed at the Gila River Resorts & Casinos in Arizona for the Hall of Fame pre-Super Bowl party early Sunday morning.
Shakira sent her best wishes to Rihanna on Super Bowl Sunday.
"What are you doing here?!" the singer demands of her husband.
The singer was joined by Academy Award-winner Troy Kotsur, who delivered an ASL rendition of "The Star Spangled Banner."
The R&B singer's rendition of the patriotic track preceded the kickoff for the championship game.
The Abbott Elementary actress is the first Black person to perform the Black national anthem on the field before the Super Bowl.
The couple star in McDonald's new commercial aired during the Super Bowl, and have created a specially curated Cardi B & Offset Meal at the fast food restaurant for fans to enjoy.
