Eminem last opened the VMAs in 2010 with “Not Afraid,” followed by a duet performance with Rihanna of “Love the Way You Lie.”
Teddy Swims and Jessie Murph are set to perform on the Extended Play Stage, and Le Sserafim will on the pre-show.
This is a reversal of what transpired last year, when the live simulcast aired on UniMás and the encore presentation aired on Univision.
Karol G & LL Cool J are also joining the roster of performers.
Of the 10 double honorees, seven are women, two are men and just one is a group.
Perry & the VMAs are almost exactly the same age: Perry was born six weeks after the inaugural VMAs aired on Sept. 14, 1984.
Camila Cabello, GloRilla and Rauw Alejandro are also set to hit the main stage.
The MTV Video Music Awards air on Sept. 10. Here's how to watch your favorite MTV shows online for free.
Ariana Grande, Eminem and Sabrina Carpenter are next on the leaderboard, with six nods each.
The show will be held just four days shy of the 40th anniversary of the inaugural VMAs at Radio City Music Hall, where Madonna stole the show.
