Christina Applegate on MS deterioration: “I don’t enjoy living”

Christina Applegate has opened up about living with multiple sclerosis, saying that she doesn’t “enjoy living” anymore.

Applegate, who is known for her roles in Dead To Me, Married…with Children and Anchorman, announced in August 2021 that she had been diagnosed with the autoimmune disease multiple sclerosis. She would go on to say two years later that she would likely never act again on camera, after the premiere of the third season of Dead To Me in November 2022.

“I can’t even imagine going to set right now,” the actor said at the time. “This is a progressive disease. I don’t know if I’m going to get worse. I can do voiceover stuff because I have to support my family and keep my brain working.”

And now, in an episode of her podcast MeSsy, which she co-hosts with The Sopranos’ Jamie-Lynn Sigler, she shared that she had been suffering from severe depression recently.

“A real fuck-it-all depression – like a real depression, where it’s kind of scaring me too a little bit because it feels really fatalistic, it feels really ‘end of’,” she said. “I don’t mean that, but I’m trapped in this darkness right now that I haven’t felt in probably 20-something years.”

“I don’t enjoy living, I don’t enjoy it,” she continued. “I don’t enjoy things anymore.”

She went on to say that she has booked an appointment with her therapist, which she has hesitated to do previously as she says she is “afraid to start crying”.

In January, Applegate made an appearance on stage at the Primetime Emmy Awards, where she presented the Best Supporting Actress in a Comedy Series award to Ayo Edebiri for The Bear.

She was supported on stage by a cane, in a rare public appearance. Accompanied by Frank Sinatra’s ‘Love And Marriage’, the theme song to Married…with Children, she stood next to host Anthony Anderson and received a huge round of applause and standing ovation, to which she responded: “You’re totally shaming me with disability by standing up, it’s fine.”

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